Open AccessCOMPARATIVE STUDIES ON THE PREVENTIVE EFFECT OF PYRIDINOLCARBAMATE AND ESTROGEN AGAINST AORTIC AND CORONARY ATHEROSCLEROSIS OF CHOLESTEROL‐FED RABBITS
Author(s) -
Numano Fujio,
Katsu Kenichi,
Takenobu Makio,
Sagara Atsushi,
Shimamoto Takio
Publication year - 1971
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1971.tb00119.x
Subject(s) - endocrinology , medicine , esterase , lipoprotein lipase , lipase , cholesterol , atpase , glycolysis , estrogen , chemistry , enzyme , biochemistry , biology , adipose tissue , metabolism
A histoenzymatic study was carried out to elucidate the anti‐atherosclerotic effect of estrogen and pyridinolcarbamate, which has been supposed to be much related to a permeability inhibiting effect. Cholesterol feeding of 15 weeks' regimen led the aortae of placebo control group to the condition of a definite reduction of glycolytic, SDH and ATPase activities, a fair reduction of 5'‐N and an increase of esterase, lipase, β‐gl and acid‐Pase activities as compared with those of regular diet group. Atheromatous lesions characterized with an accumulation of foamy cells and necrotic foci exhibited a strong acid‐Pase and β‐gl. activities and a weak reaction of lipase, esterase and glycolytic enzymes. However, in diethylstilbestrol treated and cholesterol‐fed rabbits, glycolytic, esterase, lipase, acid‐Pase and ATPase showed a more reducing activity than those of the control rabbits. A definite reduction of β‐gl, acid‐Pase and lipase, and an increase of 5'‐N activity were certified in the atheromatous lesions whose histological feature was characterized with a diffuse fibrosis. On the other hand, in the aortic wall of the rabbits treated with pyridinolcarbamate under cholesterol feeding the increase in the activities of PR, G‐6PDH, SDH and ATPase was certified. In atheromatous lesions the appearance or the increase of glycolytic enzyme and ATPase activities was especially characteristic. Other hydrolytic enzymes exhibited the same inclination of activity as those of estrogen treated group. These histoenzymatic characteristics of both substances may suggest a different way to anti‐atherosclerotic effect which is physiopa‐thologically regarded as permeability inhibiting effect and may possibly reflect in the difference of their effect or the repair process of atheromatous lesions.