Open AccessDISTRIBUTION OF VIRAL ANTIGEN IN MOUSE MAMMARY TUMOR CELLS AS REVEALED BY FERRITIN ANTIBODY CONJUGATE TECHNIQUE
Author(s) -
Okano Hiromitsu
Publication year - 1971
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1971.tb00109.x
Subject(s) - ferritin , immunoelectron microscopy , antiserum , cytoplasm , conjugate , antibody , antigen , chemistry , microbiology and biotechnology , pathology , biology , virology , immunology , biochemistry , medicine , mathematical analysis , mathematics
Rabbit antiserum against purifled type B particles from spontaneous mouse mammary tumor tissue was conjugated with ferritin for immunoelectron microscopy in order to demonstrate a relationship between type A and B particles. Ferritin granules were found deposited on type B particles and on budding A particles; some were also found similarly deposited on the naked cytoplasmic A particles. These observations suggest that type A particles contain material which is common in antigenic property to that contained in type B particles. The flndings may support the view that the naked cytoplasmic A particles are a precursor of B particles.