Open AccessEXPERIMENTAL STUDY ON INTERACTION BETWEEN THE GROWTH OF MALIGNANT TUMOR AND CONNECTIVE TISSUE WITH SPECIAL REFERENCES TO ACID MUCOPOLYSACCHARIDES
Author(s) -
Takeuchi Jun
Publication year - 1971
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1971.tb00107.x
Subject(s) - glycosaminoglycan , connective tissue , pathology , medicine , chemistry , anatomy
In order to study the interaction between connective tissue and cancer cells, the effect of acid mucopolysaccharides on the subcutaneous growth of Ehrlich ascites tumor was investigated. Chondroitin sulfate was injected subcutaneously into the back of mice, followed immediately by tumor inoculation into the same site. Average tumor weights in chondroitin sulfate‐treated groups were greater than that in control groups, showing statistically significant difference. By means of the same procedure, the effect of chondroitin sulfate and its components on the tumor growth was surveyed quantitatively with various amounts and concentrations, and its activity under the influences of other interstitial components, hydrocortisone and rechallenge was also observed. Results from this experiment indicated that chondroitin sulfate promoted the tumor growth and appear to show that the proliferation of new connective tissue which produces acid mucopolysaccharides is favorable to the growth of cancer cells. Interaction between connective tissue and tumor growth was discussed from a view‐point of intercellular components.