Open AccessINCREASE OF COLONY FORMING CELLS IN PERIPHERAL BLOOD BY HISTAMINE INJECTION
Author(s) -
SEKI Masatoshi
Publication year - 1970
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1970.tb02742.x
Subject(s) - histamine , eosinopenia , peripheral , hematocrit , peripheral blood , medicine , endocrinology , granulocytosis , hydrocortisone , chemistry , granulocyte
For the purpose to study the humoral control of defensive responses, kinetics of colony forming cells (GFC) In peripheral blood of histamine ‐injected mice was assayed by modification of McCulloch and Till's method, with usual hematological examinations. Effects of histamine on adrenalectomized mice and hydrocortisone injection into intact animals were also examined in the same manner. In conventional mice, histamine caused marked leukopenia and a rise of hematocrit value by 15 minutes after the injection, the latter of which was restored within 30 minutes. On the other hand, high hematocrit value continued for more than 1 hour in adrenalectomized mice. Histamine administration into conventional mice caused a temporary increase of peripheral CFC by 1–3 hours after the injection, accompanied by granulocytosis. Afterwards, CFG count reverted to control level. In adrenalectomized mice, count of peripheral CFG was about two times of that of control. Histamine administration into adrenalectomized mice caused remarkable increase of peripheral CFC by 3 hours after the injection. On the contrary, hydrocortisone decreased peripheral CFC count distinctly. ACTA PATH. JAP. 20: 141 ‐ 152, 1970.