Open AccessAN AUTOPSY CASE OF ALKAPTONURIA WITH OCHRONOSIS
Author(s) -
Nishimori Issei,
Itoh Junichi,
Hakuno Tohru
Publication year - 1970
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1970.tb00104.x
Subject(s) - alkaptonuria , ochronosis , autopsy , pathology , medicine , homogentisic acid , dermatology , biology , biochemistry
An autopsy case of alkaptonuria in a 47‐year‐old man is reported. Since childhood, he had noticed black color of his excreted urine. Autopsy revealed characteristic pathologic changes due to alkaptonuria such as ochronosis and ochronotic spondylosis, etc. The primary cause of death was pontine hemorrhage. Histologically, two types of ochronotic pigment were observed. Enzyme activity of homogentisate oxygenase in the liver and kidney homogenate was extremely decreased.