Open AccessAN APPROACH TO THE IMMUNOLOGICAL REGRESSION OF THE TUMOR
Author(s) -
Kobayashi Hiroshi
Publication year - 1970
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1970.tb00100.x
Subject(s) - virus , strain (injury) , biology , carcinogen , pathology , virology , medicine , anatomy , genetics
The author reported that the tumors induced by Friend virus in rats are histologically lymphosarcomas, but they do not grow well in normal isologous rats. Even when the tumors grow initially, they regress later. In the same manner as the above, when several transplantable tumors in rats, which had developed spontaneously or had been induced by chemical carcinogens, are artificially infected Friend virus, they do not grow in each susceptible strain of rats as in the Friend virus‐induced tumors. These rat tumors induced by Friend virus or artificially infected with Friend virus can grow in rats only when the host is Friend‐tolerant or immunologically depressed. The mechanism on the regression of the tumors in the rat was discussed from the viewpoint of immunopathological studies.