Open AccessELECTRON MICROSCOPIC STUDY ON THE MIDDLE CEREBRAL ARTERY LESIONS IN HYPERTENSIVE RATS
Author(s) -
Kojimahara Masayasu,
Ooneda Genju
Publication year - 1970
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1970.tb00097.x
Subject(s) - vacuole , cytoplasm , pathology , anatomy , middle cerebral artery , autophagy , cerebral arteries , smooth muscle , medicine , chemistry , biology , ischemia , microbiology and biotechnology , apoptosis , biochemistry
Changes in the middle cerebral arteries, especially in the media, of rats with experimental hypertension were electron microscopically studied. The animals whose brains showed gross hemorrhage or softening were excluded. Medial lesions were severer than intimal ones. Medial smooth muscle cells exhibited focal cytoplasmic degradation, and most of the necrotic parts were found in autophagic vacuoles. There were also vacuoles which resulted from disposal of the degraded cytoplasm in the autophagic vacuoles. The disposed necrotic parts, discharged out of the cells were seen as vesicles varying in size around the smooth muscle cells. The medial smooth muscle cells became smaller as if torn off, and finally disappeared.