Open AccessA HISTOPATHOLOGICAL STUDY ON THE EFFECT OF VARIOUS DRUGS IN EXPERIMENTAL MURINE LEPROSY
Author(s) -
Sasaki Norisuke
Publication year - 1969
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1969.tb00712.x
Subject(s) - leprosy , pathology , medicine
The effect of a high molecular unsaturated fatty acid C 22 H 36 O 2 (RTB) In the treatment of experimental murine leprosy was studied for a one‐year long term in parallel with Isonicotinic acid hydrazide (INAH), its derivatives Isonicotinoyl 3–4‐diethoxy benzol hydrazone (No. 284), and a salivary gland hormone (Parotin). The effectiveness of RTB on experimental murileproma was found to be weaker than INAH and No. 284, but almost the same as Parotin. The healing mechanism of RTB and Parotin is not a direct bacteriocidal action, but has a phagocytic and bacteriolytic mechanism of histiocytes due to activation of the reticuloendothelial system. The characteristic findings following RTB administration were predominant proliferation of “argyrophilic fiber type of histiocytes” and argyrophilic fibers, and the new formation of blood‐capillaries. At the same time, the healing process of various drugs and the non‐inhibitory effect of RTB were histopathologically discussed.