Open AccessNUCLEOLAR ALTERATIONS OF ALVEOLAR EPITHELIAL CELLS IN RATS FOLLOWING A SINGLE INJECTION OF MONOCROTALINE
Author(s) -
Hayashi Yuzo,
Hasegawa Toshiaki
Publication year - 1969
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1969.tb00710.x
Subject(s) - pathology , medicine
Nucleolar alterations characterized by disintegration of nucleolonemal structure, and segregation of granular and fibrillar components were produced in the alveolar epithelial cells of rats after an injection of monocrotaline, a pyrrolizidine alkaloid from Crotalaria spectabilis. These lesions appeared most prominently 6 hours after injection, and most of the alveolar epithelial cells, both type I and type II cells were shown to be involved. At the 24th and 48th hour, nucleolonemal strands became reorganized, and the granular component appeared to be more abundant than in the control nucleolus. The significance of these nucleolar alterations was discussed in connection with a possible biochemical action of monocrotaline on the nuclear DNA of the alveolar epithelial cells. ACTA PATH. JAP. 19: 315˜327, 1969.