Open AccessULTRASTRUCTURAL STUDIES ON GLOMERULAR LESIONS IN EXPERIMENTAL HYPERTENSION
Author(s) -
Takebayashi Shigeo
Publication year - 1969
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1969.tb00701.x
Subject(s) - basement membrane , glomerular basement membrane , ultrastructure , pathology , thickening , glomerular mesangium , medicine , endocrinology , kidney , chemistry , glomerulonephritis , polymer science
Chronological and electron microscopic studies of glomerular lesions were carried out on four different experimental hypertension groups (renal hypertension by Goldblatt, adrenal regeneration hypertension, steroid‐induced hypertension and salt hypertension) and two control groups (intact group and salt treated nonhypertension group). There was no essential difference in glomerular lesions among the four different experimental hypertension groups, and It was understood that morphological changes were consequent to the experimental methods and hypertension. The thickening of basement membrane of capillary loop was proportional to the duration of hypertension and was in no way related to the onset of hypertension. The basement membrane was undoubtedly thickened even in intact rats due to aging. The thickening of basement membrane in nonhypertensive salt treated animals appeared earlier than that in the intact group. “Mesangial cell proliferation” observed In experimental hypertension groups contained a great number of monocytes from hematogenous source which entered into the intercellular space between mesangial cells and endothelial cells. Colliculus (cytoplasmic projection of mesangial cell) had no special relationship to the elevation of blood pressure but indicated important suggestions concerning renostimulating factors and mesangial cell function.