Open AccessLETTERER‐SIWE DISEASE AND EOSINOPHILIC GRANULOMA CASE REPORT INCLUDING THE ULTRASTRUCTURAL FINDINGS OF THE HISTIOCYTES PROLIFERATING IN THESE DISORDERS
Author(s) -
Kondo Yoichiro,
Tomioka Hisao,
Itoh Mitsumasa
Publication year - 1969
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1969.tb00094.x
Subject(s) - histiocyte , eosinophilic granuloma , pathology , dermis , langerhans cell , lesion , eosinophilic , medicine , langerhans cell histiocytosis , autopsy , disease , immunology , antigen
Two autopsy cases of Letterer‐Siwe disease and a bone lesion of eosinophilic granuloma obtained at surgical operation have been presented. Electron microscopic examination of the skin lesion of one case of Letterer‐Siwe disease revealed that the histiocytes accumulating in the dermis contained characteristic Langerhans cell granules. The number of granules was variable due probably to cell maturation or activity. Similar histiocytes containing the Langerhans cell granules were observed in the bone lesion of eosinophilic granuloma. From this, it is assumed that the histocytes in these disorders have a common functional property. In addition, the possible origin of the epidermal Langerhans cell was also discussed in relation to these findings.