Open AccessON THE VASCULAR LESIONS OF THROMBOTIC THROM‐BOCYTOPENIC PURPURA WITH SPECIAL REFERENCE TO ITS PATHOGENESIS *
Author(s) -
Sugiyama Taketoshi
Publication year - 1968
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1968.tb00074.x
Subject(s) - thrombus , pathogenesis , platelet , pathology , thrombotic thrombocytopenic purpura , medicine , purpura (gastropod) , thrombocytopenic purpura , disease , endothelium , thrombosis , vascular disease , vascular permeability , cardiology , immunology , biology , ecology
Morphological studies were made on the vascular lesions of five cases of thrombotic thrombocytopenic purpura and those of other diseases as control. The occurrence of thrombi at the bifurcations of arteriolocapillary junctions was characteristic of this disease. The side of thrombus attachment strongly suggested the important role of blood flow in the establishment of the thrombi. The granular nature, contraction and end‐othelialization process of an early thrombus, together with the lack of evidence of an increased vascular permeability at the bases of early granular thrombi suggested that the mural thrombi characteristically observed in this disease were formed as a consequence of organization process of minute intravascular platelet aggregations established on the endothelial cells at the bifurcation. The possible mechanism of endothelial involvement at the bifurcation, probably a fundamental event in this disease, was discussed from the view of immune disorder of vascular endothelium.