Open AccessESSENTIAL FAMILIAL HYPERCHOLESTEREMIC XANTHOMATO‐SIS — An Autopsy Case with Special Reference to the Pathogenesis of Its Cardiovascular Lipidosis—
Author(s) -
Watanabe Teruo,
Tananka Kenzo,
Yanai Noboru
Publication year - 1968
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1968.tb00057.x
Subject(s) - medicine , pathology , autopsy , lymph , pathogenesis , major duodenal papilla , anatomy
A typical case of essential familial hypercholesteremic xanthomatosis in a 4y‐ear‐old boy is presented. Xanthomatous infiltration was observed, not only in the skin and tendons, but also in the thymus, lymph nodes, sternum, renal papilla, lungs and in the brain. Unusually extensive arterial involvements associated with myocardial infarct were observed. It was suggested that the morphogenesis of the cardiovascular lipidosis in essential familial hypercholesteremic xarithomatosis shared a similarity with that of the aortic lesions in experimental hypercholesteremia in the rabbits, and was considered to be a separate disease entity from the common atherosclerosis during adult age. ACTA PATH. JAP. 18: 319–331, 1968.