Open AccessEXPERIMENTAL STUDIES ON THE INTERACTION BETWEEN ANTI‐TYPE B STREPTOCOCCAL ANTIBODY AND THE ANIMAL HEART TISSUE *
Author(s) -
Kyogoku Masahisa
Publication year - 1968
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1968.tb00055.x
Subject(s) - connective tissue , antibody , in vivo , pathology , myocyte , stromal cell , in vitro , biology , chemistry , immunology , medicine , microbiology and biotechnology , biochemistry
The interaction between the antibody against A‐group β‐streptococci (T 6 S 43 ) and the heart muscle in vivo and in vitro were studied using several immunological techniques. The localization pattern of the anti‐streptococcus antibody on the heart muscle was different from that of other tissues in vivo, where the antibody was always limited to the stroma, vascular bed or macrophages. In the heart, the antibody was localized first on the smooth muscle of the vascular wall, then passed through it to the surrounding stromal connective tissue and attacked the adjacent heart muscle cells. The antibody was first localized on the outer surface of cell membrane, and after several hours it passed through some part of the membrane and filled up the cytoplasma. It was localized on the interpaces of myofibrils, especially on the mitochondria and other microbodies. In vitro (tissue culture) studies revealed a moderate cytotoxicity of the antibody globulin. The mode of toxic injuries seemed to be varied among the three fractions of antibody globulins; α, β and γ‐globulin. Any kind of stimuli to the knee joint considerably increased the rate of antibody localization to the joint tissue and was followed by severe exudations. It was just a temporal phenomenon, however, and returned to a normal range after 48 hours. Possible analogy of these phenomena to the human rheumatic fever was discussed. ACTA PATH. JAP. 18: 287–306, 1968.