Open AccessFIBROSIS WITH BILE DUCT PROLIFERATION IN RAT LIVER BY ORAL ADMINISTRATION OF EXCESS GLUCOSE‐CYSTEINE *
Author(s) -
Miyasaki Kichihei,
Funabiki Toshiyuki
Publication year - 1968
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1968.tb00053.x
Subject(s) - cysteine , cystine , fibrosis , oral administration , liver fibrosis , medicine , chemistry , endocrinology , bile duct , biochemistry , pathology , enzyme
Cysteine, a sulphur‐containing amino acid, is chemically unstable, being readily oxidized to become cystine. Stabilization of cysteine was, therefore, achieved by preparing a mixture with glucose and a large amount of this preparation (3–0.5 g/kg) was orally administered into rats daily for a prolonged period (3–6 months). Through administration of such a large dose, fibrosis was noted in the liver together with occasional proliferation of cholangioles. No marked change was noted in the total lipid content of the liver. ACTA PATH. JAP. 18: 249–266, 1968.