Open AccessEXPERIMENTAL PRODUCTION OF CHRONIC ULCER IN THE GLANDULAR STOMACH OF MICE BY ADMINISTRATION OF CORTISONE COMBINED WITH FASTING
Author(s) -
Kubo Toshio
Publication year - 1968
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1968.tb00050.x
Subject(s) - medicine , cortisone , atrophy , gastroenterology , hyperplasia , peptic ulcer , stomach , metaplasia , subcutaneous injection , pathology
The present author has succeeded in producing chronic gastric ulcer in CF 1 male mice, in a state of fasting, by subcutaneous administration of cortisone in large doses. It was elucidated that the process began with the formation of acute erosion which subs equently progressed to chronic ulcer. The chronic ulcer was produced within a period of 57 days from the start of the experiment. The ulcer was characterized by the presence of such mucosal fibrosis and marginal regenerates as commonly observable in chronic peptic ulcer in man. The ulcer occurred with a predilection for the pyloric area. In addition, the chronic changes in the mucosa, such as, cyst formation, intestinal metaplasia with Paneth cells, mucosal atrophy, or hyperplasia and glandular ectopia as well, were observed in many cases. ACTA PATH. JAP. 18 : 227–237, 1968.