Open AccessTHROMBUS AND COAGULATION FACTORS IN THE GENESIS OF ARTERIOSCLEROSIS
Author(s) -
Tanaka Kenzo
Publication year - 1968
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1968.tb00041.x
Subject(s) - adventitia , fibrinogen , thrombus , fibrin , medicine , autopsy , pathology , coagulation , arteriosclerosis , aorta , thromboplastin , cardiology , immunology
The incidence of thromboembolism in autopsy cases over 40 years of age was much higher in Americans than in Japanese. Atherosclerosis of the aorta was more severe in the autopsy cases with thromboembolism than in those without. Repeated intravenous administrations of either whole blood clot, fibrin clot, thromboplastin or fibrinogen produced sclerotic lesions in the pulmonary artery of rabbits, and these changes were considered to be induced not only by the encrustation of thrombi but also by the inflammatory reaction of the arterial wall. The arterial changes induced by the administration of the coagulation factors enhanced the cholesterol ‐ induced arterial changes and vice versa. Thromboplastic activity was high in the intima and low in the media and the adventitia, while fibrinolytic activity was high in the adventitia and low in the media and the intima. Fibrin or fibrinogen was occasionally demonstrated even in the macroscopically normal and microscopically fibrous‐thickened intima. These observations seem to suggest that the deposition or the infiltration of plasma proteins plays an important causative role in atherogenesis. ACTA PATH. JAP. 18 : 91 ‐106, 1968.