Open AccessEXPERMIMENTAL AMYLOIDOSIS INDUCED BY 20‐METHYLCHOLANTHRENE IN RABBITS †
Author(s) -
Hirao Fumio,
Fujisawa Tomoo,
Tsubura Eiro,
Akamatsu Yasuyuki,
Yamamura Yuichi
Publication year - 1967
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1967.tb01200.x
Subject(s) - amyloidosis , pathology , methylcholanthrene , medicine , biology , carcinogen , biochemistry
In the course of repeated intrabronchial application of 20‐methylcholanthrene to the rabbits, many of them were found to die from uremia with nephrotic syndrome. Approximately 60 % of animals, 3 months or longer under the experiment, showed swollen kidneys with the glomerular tufts deposited with amyloid and tubules dilated with hyaline casts. These lesions in the kidneys as well as in the liver, spleen and adrenals seen in 24 rabbits were consistent with systemic amyloidosis. Autofluorescence similar to that of 20‐methylcholanthrene was observed in the unstained frozen sections of the kidney at the site of amyloid deposition. Amyloidosis developed only in one rabbit of each group which received either intrabronchial application of 4‐nitroquinoline N‐oxide or intravenous administration of 20‐methylcholanthrene. Experimental procedures for inducing amyloidosis and pathogenesis of experimental amyloidosis were discussed.