Open AccessDYSGAMMAGLOBULINEMIA ASSOCIATED WITH AFFECTION OF THE CENTRAL NERVOUS SYSTEM AND APPEARANCE OF ATYPICAL LYMPHOCYTES IN PERIPHERAL BLOOD
Author(s) -
Morikawa Shigeru,
Chen Shih Tse,
Okamoto Eiichi,
Oka Masanori
Publication year - 1967
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1967.tb00029.x
Subject(s) - pathology , autopsy , central nervous system , spleen , peripheral blood mononuclear cell , lymph , immunoelectrophoresis , medicine , infiltration (hvac) , biology , antigen , immunology , endocrinology , biochemistry , physics , in vitro , thermodynamics
An autopsy case of dysgammaglobulinemia associated with affection of the central nervous system in a 61‐year‐old male was reported. Close similarity of the findings to those of the case reported by Bichel et al. was noticed. The abnormal protein observed in this case was proved to belong to IgG by ultracentrifugation, immunoelectrophoresis and fractionation on DEAE‐cellulose column. Histological characteristics were remarkable infiltration of mononuclear cells including plasma cells, proliferative changes of the vessel walls in several organs, such as the lymph nodes, spleen, lungs, etc., and demyelinating lesions were found in the central nervous system. lmmunofluorescent study revealed the presence of human y‐globulin in the infiltrates in various organs. Subacute or chronic infection by an unknown agent or hypersensitivity is suggested.