Open AccessCHEMICAL and MORPHOLOGICAL PATHOLOGY OF MERCURY DEPOSIT FOLLOWING ADMINISTRATION OF A MERCURIAL ONCOSTATIC *
Author(s) -
Mori Wataru,
Tsunakawa Shozo,
Oota Kunio,
Taguchi Hisako
Publication year - 1965
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1965.tb02896.x
Subject(s) - mercury (programming language) , autopsy , kidney , pathology , necrosis , calcification , medicine , chemistry , computer science , programming language
Summary Using autopsy cases with definite history of receiving a mercurial oncostatic, Hg‐Hematoporphyrin‐Na, chemical and morphological pathology of mercury deposit in the kidney and liver was studied. It was proved that mercury was deposited for at least 50 to 70 days in those organs and almost diminished in around 200 days. A very small dose did not cause any deposit. The kidney, especially the cortex, contained much more amount of mercury than the liver, and mercury deposit in the other organs was quite slight. Moderate number of cases showed remarkable changes of the kidney and liver histologically, degeneration of the tubular epithelium with occasional calcification in the former and central necrosis in the latter. The renal change was most probably related with the mercurials, but the hepatic damage was difficult to be attributed to the agent at the present stage of our study. Parallelism between the amount of mercury deposit and the grade of histological changes was not always clear, a fact which suggests that the effects of the mercurials varied among different individuals. It is recommended to prescribe strong agents, especially oncostatics, under the repeated control of renal and hepatic function tests.