A n A utopsy C ase of W eber ‐C hristian's D isease A ssociated with G ranulocytopenia

Summary An autopsy was performed on a 16 years old female who had complained of recurrent attacks of subcutaneous nodules with high fever, and granulocytopenia. Non‐suppurative inflammatory changes were presented in the adipose tissue of the subcutaneous, omenteric, mesenteric, peripancreatic, perirenal, and periadrenal regions. The liver showed enlargement with fatty degeneration. The liver, spleen, and the mesenteric lymph nodes had been invaded with many foamy macrophages and some multinucleated giant cells. The bone marrow revealed a denned retardation of maturity of granulocytic series by infiltration of macrophages. Under the above findings this case may be included in the type of systemic nodular panniculitis by Steinberg.