Open AccessA n A utopsy C ase of P rimary A ldosteronism
Author(s) -
Arakawa Shuji,
Ono Teiji,
Imai Yoshio
Publication year - 1957
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1957.tb03010.x
Subject(s) - primary aldosteronism , aldosterone , adenoma , hypokalemia , hyperaldosteronism , autopsy , medicine , nephrosclerosis , adrenocortical adenoma , pathology , kidney , endocrinology
Summary Regarding primary aldosteronism, 24 cases have been already reported since Conn made his first description, but among them only three were autopsy cases. Although this case had no periodic paralysis nor tetany, the existence of such findings emphasized by Conn, namely confirmation of adrenocortical adenoma and its greater content of aldosterone, hypokalemia and the existence of the conspicuous hydropic degeneration in the tubular epithelium of the kidney and other clinical findings may indicate a primary aldosteronism. There have been no reports of malignant nephrosclerosis which was based upon primary aldosteronism. Although the probability that the malignant hypertension and adrenocortical adenoma co‐existed independently could not be wholly denied, at least in this case because of the greater amount of aldosterone in the adrenocortical adenoma, being proved in the clinical examination, it would be reasonable to consider that the hypertension may have occurred as a result of the hypersecretion of aldosterone and from this condition malignant nephrosclerosis might have been developed.