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Neuropsychological performance in euthymic I ndian patients with bipolar disorder type I : Correlation between quality of life and global functioning
Author(s) -
Pattanayak Raman Deep,
Sagar Rajesh,
Mehta Manju
Publication year - 2012
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.2012.02400.x
Subject(s) - bipolar disorder , cognitive flexibility , neuropsychology , verbal memory , cognition , psychology , executive functions , working memory , quality of life (healthcare) , effects of sleep deprivation on cognitive performance , clinical psychology , audiology , psychiatry , medicine , psychotherapist
Aim This study aims to assess the neuropsychological performance, quality of life ( Q o L ) and global functioning in euthymic patients and healthy controls. It also explores the hypothesis that poorer cognitive performance will adversely influence the Q o L of patients with bipolar disorder. Methods We carried out a cross‐sectional assessment of 30 euthymic patients with bipolar disorder type I and compared them to a healthy control group. All the participants were evaluated for IQ , sustained attention, information processing speed, executive functions and memory using the V erbal A dult I ntelligence S cale, the T rail M aking T est A & B , the S troop C olor and W ord T est, the N ‐ B ack test and P ostgraduate I nstitute M emory S cale. Patients were also rated on W orld H ealth O rganization Q o L ( BREF , H indi version) and G lobal A ssessment of F unctioning. Results The patient and control group were comparable in age, sex distribution, education, and verbal IQ . Compared to controls, the patients performed poorly on tests for sustained attention, information processing speed, cognitive flexibility, delayed recall and verbal retention. Patients had significantly lower scores in psychological and social domains of Q o L as well as global functioning. The test for sustained attention, executive functions and verbal retention showed a significant correlation to Q o L domains. On stepwise multiple regression, cognitive flexibility and set shifting ( T rail M aking T est P art B ) could significantly predict the psychological and social Q o L domains, explaining 17% and 32% of the variance, respectively. Conclusion Patients with bipolar disorder display cognitive impairments in the euthymic period, which appears to adversely affect their Q o L and overall functioning.