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Clinical correlates associated with cognitive dysfunction in people with schizophrenia
Author(s) -
Tanaka Tsunehiko,
Tomotake Masahito,
Ueoka Yoshinori,
Kaneda Yasuhiro,
Taniguchi Kyoko,
Nakataki Masahito,
Numata Shusuke,
Tayoshi Shinya,
Yamauchi Ken,
Sumitani Satsuki,
Ohmori Takashi,
Ueno Shuichi,
Ohmori Tetsuro
Publication year - 2012
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.2012.02390.x
Subject(s) - positive and negative syndrome scale , schizophrenia (object oriented programming) , cognition , verbal fluency test , psychology , extrapyramidal symptoms , psychiatry , psychosis , cognitive deficit , working memory , medicine , clinical psychology , depression (economics) , neuropsychology , antipsychotic , cognitive impairment , economics , macroeconomics
Aims The purpose of the present study was to investigate the correlation between cognitive function and clinical variables in people with schizophrenia. Methods The subjects were 61 stabilized outpatients with schizophrenia ( DSM‐IV ). Their mean age was 40.1 ( SD = 12.2) years. All subjects gave written informed consent to participate in the research. Cognitive function was evaluated using the Brief Assessment of Cognition in Schizophrenia. Clinical symptoms were assessed using the Positive and Negative Syndrome Scale, the Calgary Depression Scale for Schizophrenia, and the Drug‐Induced Extrapyramidal Symptoms Scale. Results The Positive and Negative Syndrome Scale Negative syndrome score was significantly correlated with verbal memory score (r = −0.37, P < 0.01), working memory score (r = 0.38, P < 0.01), attention and speed of information processing score (r = −0.51, P < 0.01), verbal fluency score (r = −0.39, P < 0.01), and composite score (r = −0.54, P < 0.01). In addition, the Drug‐Induced Extrapyramidal Symptoms Scale score was significantly correlated with attention and speed of information processing (r = −0.45, P < 0.01), and composite score (r = −0.41, P < 0. 01). Dose of antipsychotics and anti‐Parkinson drugs was not significantly correlated with the Brief Assessment of Cognition in Schizophrenia scores. Conclusions These results indicate that cognitive dysfunction of people with schizophrenia might be associated with negative and drug‐induced extrapyramidal symptoms, suggesting that their minimization would be important for improving cognitive dysfunction.