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Cerebral blood flow changes in very‐late‐onset schizophrenia‐like psychosis with catatonia before and after successful treatment
Author(s) -
Tsujino Naohisa,
Nemoto Takahiro,
Yamaguchi Taiju,
Katagiri Naoyuki,
Tohgi Nao,
Ikeda Ryu,
Shiraga Nobuyuki,
Mizumura Sunao,
Mizuno Masafumi
Publication year - 2011
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.2011.02257.x
Subject(s) - catatonia , cerebral blood flow , psychosis , thalamus , psychology , schizophrenia (object oriented programming) , temporal cortex , striatum , single photon emission computed tomography , perfusion , neuroimaging , cortex (anatomy) , cerebral cortex , medicine , neuroscience , cardiology , psychiatry , anesthesia , dopamine
The purpose of the present study was to investigate regional cerebral blood flow (rCBF) changes in a patient with very‐late‐onset schizophrenia‐like psychosis (VLOS) with catatonia. A 64‐year‐old woman developed catatonia after experiencing persecutory delusions. The patient's rCBF was examined using single photon emission computed tomography (SPECT) with easy Z‐score imaging system. Before treatment, hypoperfusion was observed in the striatum and the thalamus, whereas hyperperfusion was observed in the left lateral frontal cortex and the left temporal cortex. After treatment, the disproportions in rCBF disappeared, and hyperperfusion was observed in the motor cortex. Sequential SPECT findings suggest that rCBF abnormalities may be correlated with the symptomatology of catatonia in patients with VLOS.