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Reduced central white matter volume in autism: Implications for long‐range connectivity
Author(s) -
Jou Roger J.,
Mateljevic Natasa,
Minshew Nancy J.,
Keshavan Matcheri S.,
Hardan Antonio Y.
Publication year - 2011
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.2010.02164.x
Subject(s) - white matter , autism , brain size , neuroscience , psychology , volume (thermodynamics) , medicine , developmental psychology , magnetic resonance imaging , physics , radiology , quantum mechanics
Cortical and central white matter (WM) volumes were measured to assess short‐ and long‐range connectivity in autism, respectively. Subjects included 23 boys with autism and 23 matched controls, all without intellectual disability. Magnetic resonance imaging data obtained at 1.5 T were analyzed using BRAINS2 software (University of Iowa, Iowa City, IA, USA). Central WM volume was quantified by subtracting cortical from supratentorial WM volumes. Reduced central WM volume was observed in the autism group. IQ was higher in controls with no observed correlations between WM volumes and IQ. This preliminary evidence of reduced central WM volume in autism suggests abnormal long‐range connectivity.