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Fronto‐limbic abnormalities in a patient with compulsive hoarding: a 99m Tc‐ECD SPECT study
Author(s) -
Ohtsuchi Hiromasa,
Matsuo Koji,
Akimoto Takashi,
Watanabe Yoshifumi
Publication year - 2010
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.2010.02120.x
Subject(s) - hoarding (animal behavior) , pathophysiology , limbic system , abnormality , hoarding disorder , psychology , ventral striatum , neuroscience , medial frontal gyrus , perfusion , anterior cingulate cortex , cerebral blood flow , striatum , medicine , psychiatry , central nervous system , cognition , feeding behavior , dopamine
Little is known about the neuronal mechanism underpinning the pathophysiology of compulsive hoarding. We report the cerebral blood flow changes in an obsessive‐convulsive patient with severe hoarding. The patient showed hyperperfusion of the fronto‐temporal region and hypoperfusion of the striatal, the middle cingulate and the medial temporal regions during the stage with severe symptoms. Following improvement from the hoarding behaviors, the extent of hypoperfusion was expanded in the bilateral striatum, the anterior and middle cingulate gyrus. The result may substantiate evidence of the fronto‐limbic abnormality involved in the pathophysiology of compulsive hoarding.