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Administration of zonisamide in three cases of dementia with Lewy bodies
Author(s) -
Odawara Toshinari,
Shiozaki Kazumasa,
Togo Takashi,
Hirayasu Yoshio
Publication year - 2010
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.2010.02075.x
Subject(s) - zonisamide , dementia with lewy bodies , dementia , medicine , parkinson's disease , motor symptoms , disease , pediatrics , anesthesia , psychiatry , epilepsy , topiramate
Zonisamide (ZNS) add‐on administration was used to treat parkinsonian symptoms in three cases of dementia with Lewy bodies (DLB). ZNS was added after doses of the anti‐Parkinson's disease drugs were fixed for at least 4 weeks. A total of 25 mg of ZNS produced mild–moderate improvement of parkinsonian symptoms in two cases, but it did not affect the cognitive functions and behavioral or psychological symptoms. Caregiver burdens were decreased in two cases. Although dizziness and drowsiness were detected, these were improved by decreasing the dose. ZNS may be useful for the treatment of motor symptoms in DLB patients.