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Temporal cortex dopamine D 2/3 receptor binding in major depression
Author(s) -
Lehto Soili M.,
Kuikka Jyrki,
Tolmunen Tommi,
Hintikka Jukka,
Viinamäki Heimo,
Vanninen Ritva,
Haatainen Kaisa,
KoivumaaHonkanen Heli,
Honkalampi Kirsi,
Tiihonen Jari
Publication year - 2008
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.2008.01814.x
Subject(s) - dopamine , neuroscience , depression (economics) , temporal cortex , dopamine receptor d3 , dopamine receptor d2 , psychology , economics , macroeconomics
The aim of this study was to assess the dopamine function of the temporal cortex in major depressive disorder using [ 123 I]epidepride to image D 2/3 receptor binding sites. Ten major depressives and 10 healthy controls were selected from a general population sample for single‐photon emission computed tomography imaging. Among the major depressives there was a strong bilateral correlation between the scores on the 21‐item Hamilton Depression Rating Scale and D 2/3 receptor binding. Dopaminergic abnormalities may be present in the temporal cortices of major depressives.