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Persistent generalized anxiety after brief exposure to the dopamine antagonist metoclopramide
Author(s) -
KLUGE MICHAEL,
SCHÜSSLER PETRA,
STEIGER AXEL
Publication year - 2007
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.2007.01637.x
Subject(s) - metoclopramide , anxiety , dopamine antagonist , panic , antagonist , dopamine , dopaminergic , medicine , generalized anxiety disorder , psychology , generalized anxiety , panic disorder , psychiatry , anesthesia , haloperidol , receptor , vomiting
The authors describe a 31‐year‐old woman who developed persistent generalized anxiety after brief exposure to the dopamine antagonist metoclopramide. Independently of that, she had experienced a panic attack followed by dystonias, shortly after a single dose of that drug, 17 years before. Both temporal association and recurrence of anxiety symptoms after re‐challenge with metoclopramide suggest a causal relationship. The case might provide an initial piece of evidence that dopaminergic neurotransmission can be involved in the pathogenesis of generalized anxiety disorder.