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Association study of a functional promoter polymorphism of the X‐box binding protein 1 gene in Japanese patients with schizophrenia
Author(s) -
WATANABE YUICHIRO,
FUKUI NAOKI,
MURATAKE TATSUYUKI,
AMAGANE HIDEKI,
KANEKO NAOSHI,
NUNOKAWA AYAKO,
SOMEYA TOSHIYUKI
Publication year - 2006
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.2006.01570.x
Subject(s) - genetics , allele , genotype , polymorphism (computer science) , promoter , schizophrenia (object oriented programming) , biology , gene , genetic association , medicine , single nucleotide polymorphism , psychiatry , gene expression
The functional promoter polymorphism −116C/G of the X‐box binding protein 1 ( XBP1 ) gene was found to be associated with schizophrenia in Han Chinese and Japanese subjects, although contradictive negative findings were also reported in European populations. To confirm this association in a Japanese population, the authors conducted a case‐control association study. There was no significant difference in both genotype and allele frequencies between the patients and control subjects, suggesting that the XBP1 – 116C/G polymorphism might not confer increased susceptibility for schizophrenia in a Japanese population. However, further studies using a larger sample with detailed clinical data should be performed in several populations.