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Efficacy of milnacipran on cognitive dysfunction with post‐stroke depression: Preliminary open‐label study
Author(s) -
SATO SHINJI,
YAMAKAWA YURIKO,
TERASHIMA YASUSHI,
OHTA HITOSHI,
ASADA TAKASHI
Publication year - 2006
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.2006.01562.x
Subject(s) - milnacipran , post stroke depression , depression (economics) , rating scale , psychology , reuptake inhibitor , stroke (engine) , mood , medicine , anesthesia , psychiatry , serotonin , activities of daily living , developmental psychology , mechanical engineering , receptor , engineering , economics , macroeconomics
The aim of this study was to assess the therapeutic efficacy of the serotonin norepinephrine reuptake inhibitor (SNRI), milnacipran, on both cognitive impairment and depression in post‐stroke depression (PSD) patients. A total of 18 PSD patients, approximately 3 months after stroke, were divided into two groups, milnacipran and control. A total of 10 patients were assigned to the milnaciprane group and eight were assigned to control group. Their cognitive impairment and mood symptoms were measured using the Mini‐Mental State Examination (MMSE) and Hamilton Depression Rating Scale (HAM‐D) both at the time of admission and at discharge, an interval of approximately 3 months. This study examined the changes in both MMSE and HAM‐D scores during the study period. A significant time‐by‐group interaction for results of the MMSE was observed, although there was no significant difference between the two groups on the HAM‐D. Amelioration of cognitive impairment was greater in the milnacipran group than the control group. For PSD patients, milnacipran is effective in improving cognitive dysfunction.