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Association between corticotropin‐releasing hormone receptor 2 ( CRHR2 ) gene polymorphism and personality traits
Author(s) -
TOCHIGI MAMORU,
KATO CHIEKO,
OTOWA TAKESHI,
HIBINO HIROYUKI,
MARUI TETSUYA,
OHTANI TOSHIYUKI,
UMEKAGE TADASHI,
KATO NOBUMASA,
SASAKI TSUKASA
Publication year - 2006
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.2006.01541.x
Subject(s) - neuroticism , psychology , big five personality traits , openness to experience , medicine , hormone , endocrinology , corticotropin releasing hormone , polymorphism (computer science) , anxiety , personality , gene , genetics , allele , biology , psychiatry , social psychology
Corticotropin‐releasing hormone (CRH) has been implicated in the pathophysiology of anxiety disorders and depression. Corticotropin‐releasing hormone receptor 2 (CRHR2) is one of the receptors that mediate CRH signal. The purpose of the present study was to investigate the association between the CRHR2 gene and personality traits, evaluated using the Revised NEO Personality Inventory (NEO PI‐R), in 243 healthy Japanese subjects. As a result, significant association was observed between the polymorphism in intron 2 (rs2267717) and Openness ( P = 0.004, uncorrected, anova ), while no relationship was observed concerning Neuroticism. The present result suggests an association between CRHR2 and the personality trait of Openness.