Premium
Linkage disequilibrium in aquaporin 4 gene and association study with schizophrenia
Author(s) -
MURATAKE TATSUYUKI,
FUKUI NAOKI,
KANEKO NAOSHI,
AMAGANE HIDEKI,
SOMEYA TOSHIYUKI
Publication year - 2005
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.2005.01420.x
Subject(s) - linkage disequilibrium , haplotype , schizophrenia (object oriented programming) , genetic association , genetics , aquaporin 4 , snp , linkage (software) , single nucleotide polymorphism , biology , allele , gene , medicine , psychiatry , genotype
Aquaporin 4 (AQP4) has an important role in water homeostasis of human brain and a dysfunction of AQP4 could induce pathological conditions in neuronal activity. Several genome scan studies for schizophrenia found a suggestive linkage on 18q, where human AQP4 (18q11.2–12.1) is located nearby. A case‐control study was performed which comprised 261 schizophrenia subjects and 278 controls from the Japanese population with four SNP markers. We found strong linkage disequilibrium (LD) and an LD block in the AQP4 gene but found no association between AQP4 and schizophrenia, both single SNP and haplotype analyses. The present study shows that AQP4 is not directly associated with schizophrenia in these Japanese patients.