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Relation between cortical dopamine D 2 receptor occupancy and suppression of conditioned avoidance response in non‐human primate
Author(s) -
TAKANO AKIHIRO,
SUHARA TETSUYA,
MAEDA JUN,
ANDO KIYOSHI,
OKAUCHI TAKASHI,
OBAYASHI SHIGERU,
NAKAYAMA TAKASHI,
KAPUR SHITIJ
Publication year - 2004
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.2004.01240.x
Subject(s) - haloperidol , dopaminergic , dopamine , avoidance response , dopamine receptor , neuroscience , primate , occupancy , receptor , dopamine receptor d2 , psychology , medicine , biology , ecology
Suppression of the conditioned avoidance response (CAR), a useful test for screening for antipsychotic effects, has been discussed in relation to the blockade of dopaminergic transmission. The purpose of the present paper was to investigate the relationship between cortical dopamine D 2 receptor occupancy and the suppression of CAR by haloperidol in non‐human primate. The avoidance rate was measured for four different doses of haloperidol treatment in a rhesus monkey, and the cortical D 2 receptor occupancy was measured in a parallel session using positron emission tomography with [ 11 C]FLB 457. The successful avoidance response rate was decreased for doses of 10 and 30 µg/kg of haloperidol, and this decrement was associated with 65–77% of D 2 receptor occupancy. It is suggested that the threshold level of cortical dopamine D 2 receptor occupancy for the suppression of CAR is demonstrated in the present study.