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Human leukocyte antigen‐DQB1 alleles are not associated with schizophrenia in Kuwaiti Arabs
Author(s) -
HAIDER MOHAMMAD Z.,
ZAHID MOHAMMAD A.
Publication year - 2004
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.2004.01225.x
Subject(s) - allele , human leukocyte antigen , locus (genetics) , schizophrenia (object oriented programming) , polymerase chain reaction , genetics , psychosis , medicine , biology , gene , immunology , psychiatry , antigen
Schizophrenia is among the most severe and debilitating of psychiatric disorders and has a complex mode of inheritance. A susceptibility locus has been identified on chromosome 6 and some association studies involving human leukocyte antigen (HLA) genes have reported diverse results. The objective of the present study was to determine if there is an association between HLA‐DQB1 alleles and schizophrenia in Kuwaiti Arabs. The frequency of HLA‐DQB1 alleles was determined in a cohort of 195 Kuwaiti Arabs consisting of 81 schizophrenia patients and 114 ethnically matched healthy controls, using a polymerase chain reaction–sequence specific primers method. A total of nine DQB1 alleles were identified in this Kuwaiti cohort. The most prevalent DQB1 alleles in Kuwaiti schizophrenia patients were *0601 (28%), *0201 (23%) and *0501 (16%), respectively. However, no significant difference in the allele frequency was detected between schizophrenia patients and the controls. The DQB1*0602 allele, which has been negatively associated in African–Americans in previous reports, was not detected in the present Kuwaiti schizophrenia patients or controls.