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Effect of the combination of naltrexone and acamprosate on alcohol intake in mice
Author(s) -
KIM SUNGGON,
HAN BYEUNGDEUK,
PARK JEMIN,
KIM MYUNGJUNG,
STROMBERG MICHAEL F.
Publication year - 2004
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.2004.01189.x
Subject(s) - naltrexone , acamprosate , alcohol , alcohol consumption , pharmacology , alcohol dependence , alcohol intake , ethanol , medicine , chemistry , anesthesia , psychology , biochemistry , antagonist , receptor
Both naltrexone and acamprosate have been utilized clinically in recovering alcoholics with varying success. In the experiment reported here the combination of naltrexone and acamprosate was examined in a limited access alcohol model using C57BL/6 mice to determine if there was evidence of additive or synergistic effects. The results of this experiment demonstrate that naltrexone, at the higher dose but not the lower dose, significantly reduced alcohol consumption. When combined with naltrexone, acamprosate reduced alcohol consumption across both doses of naltrexone. This effect was sensitive to both dose and number of days of exposure to the naltrexone/acamprosate combination.