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Efficacy and pharmacokinetics of fluvoxamine maleate in patients with mild depression undergoing hemodialysis
Author(s) -
KAMO TOSHIKO,
HORIKAWA NAOSHI,
TSURUTA YUKIO,
MIYASITA MISAKO,
HATAKEYAMA HIROSHI,
MAEBASHI YASUHIKO
Publication year - 2004
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.2003.01206.x
Subject(s) - fluvoxamine , hemodialysis , pharmacokinetics , depression (economics) , plasma concentration , medicine , plasma levels , anesthesia , serotonin , fluoxetine , receptor , economics , macroeconomics
Seven Japanese patients on maintenance hemodialysis who were comorbid with mild depression were medicated with 50 mg/day fluvoxamine maleate for 28 days. Effectiveness was obtained in four out of seven patients (57%). The plasma fluvoxamine concentrations were examined in three patients. The plasma fuvoxamine concentration decreased by 22% by hemodialysis. There is a tendency for the dialyzed rate of fluvoxamine to become lower if the plasma albumin concentration is higher. The half‐life of fluvoxamine was possibly shortened more in the patient with hypoalbuminaemia. The plasma fluvoxamine concentration reached a steady state 8 days after the start of medication and thereafter. The time required to reach steady state was lengthened when compared with the results in normal Japanese volunteers.