Premium
Time course of saliva and serum melatonin levels after ingestion of melatonin
Author(s) -
SHIRAKAWA SHINICHIROU,
TSUCHIYA SATOSHI,
TSUTSUMI YASUMASA,
KOTORII TSUYOSHI,
UCHIMURA NAOHISA,
SAKAMOTO TETSUROU,
YAMADA SHIGETO
Publication year - 1998
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1998.tb01067.x
Subject(s) - melatonin , ingestion , saliva , medicine , endocrinology , physiology , psychology
Abstract Salival and serum melatonin levels after melatonin ingestion were measured by gas chromatography‐mass spectrometry. Ingestion of 3 mg melatonin caused a marked increase in serum melatonin (3561 ± 1201 pg/mL) within 20 min, followed by a gradual decrease, but the level still remained higher than the basal level at 240 min after the ingestion. The saliva melatonin 60 min after the ingestion showed the highest level (1177 ± 403 pg/mL) which was one‐third of the plasma level. The saliva melatonin level was highly correlated with the serum level throughout the experimental period ( r = 0.82, P = 0.0001). These data indicate that the measurement of saliva melatonin level may be a suitable indicator for the melatonin secretion into general circulation.