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Efficacy of L‐846 in patients with insomnia:Evaluation by polysomnography
Author(s) -
SAKAMOTO TETSURO,
UCHIMURA NAOHISA,
MUKAI MASAKI,
MIZUMA HIKARI,
SHIRAKAWA SHINICHIRO,
NAKAZAWA YOICHI
Publication year - 1998
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1998.tb01003.x
Subject(s) - insomnia , polysomnography , sleep onset latency , hypnotic , slow wave sleep , sleep onset , psychology , sleep (system call) , medicine , anesthesia , audiology , psychiatry , electroencephalography , apnea , operating system , computer science
The effects of L‐846, an ultra‐short‐acting pyrazolopyrimidine hypnotic, on sleep were studied in nine insomniacs and two neurotic patients with insomnia. The patients were randomly assigned to receive 5 mg ( n = 6) or 10 mg ( n = 5) L‐846. The study schedule comprised of one adaptation night, two baseline nights, three drug nights, and two withdrawal nights. Sleep latency and slow wave sleep (SWS) latency was largely shortened and %SWS increased in the early phase of sleep. No clear evidence of rebound insomnia was noted.