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Vitamin B 12 treatment for delayed sleep phase syndrome: A multi‐center double‐blind study
Author(s) -
OKAWA M.,
TAKAHASHI K.,
EGASHIRA K.,
FURUTA H.,
HIGASHITANI Y.,
HIGUCHI T.,
ICHIKAWA H.,
ICHIMARU Y.,
INOUE Y.,
ISHIZUKA Y.,
ITO N.,
KAMEI K.,
KANEKO M.,
KIM Y.,
KOHSAKA M.,
KOMORI T.,
KOTORII T.,
MATSUMOTO M.,
MISHIMA K.,
MIZUKI Y.,
MORIMOTO K.,
NAGAYAMA H.,
OHTA T.,
OKAMOTO N.,
SAKAMOTO K.,
SHIRAKAWA S.,
SUGITA Y.,
TAMIYA S.,
YAMADA N.,
YAMADERA H.,
YAMAZAKI J.,
TAKAHASHI S.
Publication year - 1997
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1997.tb03198.x
Subject(s) - methylcobalamin , delayed sleep phase , placebo , medicine , mood , double blind , sleep disorder , psychology , anesthesia , vitamin b12 , psychiatry , insomnia , alternative medicine , pathology
The active form of vitamin B 12 (methylcobalamin) has been reported to be effective on sleep‐wake rhythm disorders. Previous studies, however, were performed under open trial, and the effect of vitamin B 12 has not been properly evaluated. The aim of this double‐blind study was to investigate the efficacy of methylcobalamin on delayed sleep phase syndrome (DSPS). Methylcobalamin (3 mg/day) or placebo was administered for 4 weeks. The subjects were 50 patients with DSPS aged 13–55 years (26.8 ± 1.3), 27 of whom received the active drug while 23 received the placebo. No significant differences were observed between the 2 groups in subjective evaluations of mood or drowsiness during the daytime or in night sleep by sleep‐log evaluation. These results indicate that 3 mg methylcobalamin administered over 4 weeks is not an effective treatment for DSPS.