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A case of Turner syndrome with schizophrenia: Genetic relationship between Turner syndrome and psychosis
Author(s) -
KAWANISHI CHIAKI,
KONO MASAAKI,
ONISHI HIDEKI,
ISHII NORIO,
ISHII KAZUHIKO
Publication year - 1997
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1997.tb02912.x
Subject(s) - turner syndrome , psychosis , daughter , schizophrenia (object oriented programming) , abnormality , psychology , turner's syndrome , chromosomal abnormality , karyotype , psychiatry , pediatrics , genetics , medicine , chromosome , biology , evolutionary biology , gene
An 82‐year‐old woman with Turner syndrome and schizophrenia, and her 46‐year‐old daughter with schizophrenia are described. 45X/46XX chromosomal mosaicism was identified in the peripheral leukocytes of the mother, who showed several Turner dysmorphisms and cavum septi pellucidum in the brain. She had a normal reproductive life‐span. The daughter resembled the mother in terms of schizophrenic symptoms, but she did not show any signs of Turner dysmorphism or chromosomal abnormality. The phenotype‐karyotype relationship of Turner syndrome and the genetic relationship with psychosis are discussed.