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Valproate lowered the amplitude of visual and somatosensory evoked potentials in two cases of untreated juvenile myoclonic epilepsy
Author(s) -
KANAZAWA OSAMU,
NAGAFUJI HIROSHI
Publication year - 1997
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1997.tb02612.x
Subject(s) - juvenile myoclonic epilepsy , somatosensory evoked potential , visual evoked potentials , evoked potential , anesthesia , epilepsy , audiology , somatosensory system , electroencephalography , myoclonus , myoclonic epilepsy , psychology , medicine , neuroscience
The amplitude of flash visual evoked potential (F‐VEP) and somatosensory evoked potential (SEP) was found to be initially slightly higher in two untreated patients with juvenile myoclonic epilepsy (JME). Patients were studied before and after complete control of seizures with valproate. In both patients valproate prolonged the latencies of the waves IV and V and lowered the amplitudes of waves V and VI of the F‐VEP. The N20–P25 amplitude in SEP in both patients was also lowered by valproate. These results may suggest that slightly higher cortical excitability in untreated JME was controlled by valproate.