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An association study between the Cys311 variant of dopamine D 2 receptor gene and schizophrenia in the Okinawan population
Author(s) -
KANESHIMA MIZUE,
RIGA TSUKASA,
NAKAMOTO HARUO,
NAGAMINE MASURU
Publication year - 1997
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1997.tb02603.x
Subject(s) - schizophrenia (object oriented programming) , allele , polymorphism (computer science) , dopamine receptor d2 , psychosis , dopamine , allele frequency , association (psychology) , dopamine receptor , population , gene , genetics , psychiatry , medicine , psychology , biology , psychotherapist , environmental health
Neuroleptic drugs have a high affinity for the dopamine D 2 receptor (DRD2); therefore DRD2 is thought to be a candidate gene for schizophrenia. Arinami et al . have reported a positive association between schizophrenia and the Cys311 variant of the DRD2 gene. We determined the allele frequency of this polymorphism in 78 Okinawan schizophrenic patients and 112 control subjects. The patients and controls did not differ significantly in allele frequencies of Cys311.