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Metabolite changes with age measured by proton magnetic resonance spectroscopy in normal subjects
Author(s) -
FUKUZAKO HIROSHI,
HASHIGUCHI TOMO,
SAKAMOTO YASUHIRO,
OKAMURA HISATAKA,
DOI WATARU,
TAKENOUCHI KAORU,
TAKIGAWA MORIKUNI
Publication year - 1997
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1997.tb02595.x
Subject(s) - phosphocreatine , creatine , metabolite , frontal lobe , temporal lobe , proton magnetic resonance , magnetic resonance imaging , nuclear magnetic resonance , medicine , chemistry , anatomy , psychology , neuroscience , physics , radiology , epilepsy , energy metabolism
To determine whether there are metabolite changes in the left medial temporal and frontal lobes with aging, we performed proton magnetic resonance spectroscopy in 36 normal subjects. The N‐acetylaspartate/creatine‐phosphocreatine ratio in the medial temporal lobe tended to be decreased in subjects over 60 years of age. The ratio decrease in the frontal lobe related to aging was lower than that in the medial temporal lobe. There were no significant differences in the metabolite ratios between males and females. These findings suggest that structures in the medial temporal lobe may be more susceptible to neuronal dysfunction associated with aging than those in the frontal lobe.