z-logo
Premium
Neurons and extracellular neurofibrillary tangles in the hippocampal subdivisions in early‐onset familial Alzheimer's disease: A case study
Author(s) -
FUKUTANI YUKEN,
SASAKI KAZUO,
MUKAI MASAMI,
MATSUBARA ROKURO,
ISAKI KIMINORI,
CAIRNS NIGEL J.
Publication year - 1997
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1997.tb02588.x
Subject(s) - neuroscience , hippocampal formation , extracellular , alzheimer's disease , disease , early onset alzheimer's disease , psychology , medicine , pathology , biology , genetics
  We have investigated morphometrically unaffected neurons, intracellular neurofibrillary tangles (I‐NFT) and extracellular neurofibrillary tangles (E‐NFT) in eight subdivisions of the hippocampal cortex in two cases of early‐onset familial Alzheimer's disease (FAD) and six cases of early‐onset sporadic Alzheimer's disease (SAD). The hippocampal subdivisions examined included: CA4, CA3, CA2, CAI, prosubiculum, subiculum and presubiculum (PRE), parasubiculum (PARA) and entorhinal cortex (ENT). CA3, CA2 and CAI in the FAD cases showed more severe neuronal loss and much greater E‐NFT formation than in the SAD cases, while ENT in both the FAD cases showed less neuronal loss and less E‐NFT formation. These data suggest that the cornu ammonis is affected more severely than the ENT in the FAD cases. These observations indicate that hippocampal pathology in the FAD cases is qualitatively as well as quantitatively different from that in sporadic cases. These results provide further evidence for pathological heterogeneity in AD, although the number of FAD cases examined is very small.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here