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Identification of monocyte chemoattractant protein‐1 in senile plaques and reactive microglia of Alzheimer's disease
Author(s) -
ISHIZUKA KOKO,
KIMURA TAKEMI,
IGATAYI RURIKO,
KATSURAGI SHOICHI,
TAKAMATSU JUNICHI,
MIYAKAWA TAIHEI
Publication year - 1997
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1997.tb02375.x
Subject(s) - senile plaques , microglia , monocyte , alzheimer's disease , pathology , amyloid (mycology) , amyloid beta , medicine , immunology , inflammation , disease
It has been shown that human monocytes express monocyte chemoattractant protein‐1 (MCP‐1), an inflammatry factor, in response to non‐fibrillar β‐amyloid protein. Reactive microglia and inflammatory factors were reported to be present in β‐amyloid deposits (senile plaques) in Alzheimer's disease, suggesting the presence of MCP‐1 in senile plaques. To address this issue, we examined MCP‐1‐immunoreactivity in senile plaques using a mouse monoclonal anti‐MCP‐1 antibody. Monocyte chemoattractant protein‐1 was found immunohistochemically in mature senile plaques and reactive microglia but not in immature senile plaques of brain tissues from five patients with Alzheimer's disease. These findings suggest that MCP‐1‐related inflammatory events induced by reactive microglia contribute to the maturation of senile plaques.