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Hallucinations after a therapeutic dose of benzodiazepine hypnotics with co‐administration of erythromycin
Author(s) -
TOKINAGA NOBORU,
KONDO TSUYOSHI,
KANEKO SUNAO,
OTANI KOICHI,
MIHARA KAZUO,
MORITA SHIGERU
Publication year - 1996
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1996.tb00577.x
Subject(s) - nitrazepam , triazolam , benzodiazepine , lorazepam , erythromycin , anxiety , medicine , diazepam , anesthesia , alprazolam , oral administration , therapeutic effect , psychology , psychiatry , pharmacology , antibiotics , receptor , microbiology and biotechnology , biology
A case of repetitive hallucinations during treatment with a therapeutic dosage of triazolam (0.25 mg/day) and nitrazepam (5 mg/day) is presented. The patient suffered from acute pneumonia and chronic renal failure. Such non‐psychotic symptoms as anxiety, tremor and depressed feeling were observed initially. However, after co‐administration of erythromycin (600 mg/day), visual hallucinations and abnormal bodily sensations developed repeatedly after each administration of triazolam or nitrazepam. This report suggests that benzodiazepine hypnotics even at a therapeutic dosage with co‐administration of erythromycin causes serious psychotic symptoms in vulnerable patients with physical complications.