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The influence of physical restraint or fasting on plaque‐forming cell response in mice
Author(s) -
KOMORI TERUHISA,
FUJIWARA RYOICHI,
SHIZUYA KOJI,
MIYAHARA SATORU,
NOMURA JUNICHI
Publication year - 1996
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1996.tb00567.x
Subject(s) - cell , medicine , biology , genetics
This study was designed to investigate the effects of 1‐ and 3‐day (16 h/day) physically restrained or fasting on immunological and endocrine responses in CBF1 mice. The influence of stressors on these responses was evaluated using anti‐sheep red blood cell plaque‐forming assay, and by examining T cell subsets, thymus weight and endocrine hormone levels. The results revealed that a significant elevation of the plaque‐forming cells (PFC) was found in spleen cells in 1‐day restrained mice, that the PFC were conversely suppressed following 3‐day physically restrained stress, and that the PFC were not affected by 1‐ or 3‐day fasting stress. Serum levels of norepinephrine were found to be significantly increased only in 1‐day physically restrained mice. No change of T cell subsets and thymus weight was found in 1‐day physically restrained mice. A significant increase in serum corticosterone levels was elicited in both 1‐ and 3‐day physically restrained mice, and 3‐day fasting mice, while increased Lyt2‐positive T cells and thymic atrophy were found only in 3‐day physically restrained mice. These findings suggest that immune function was differentially affected by the duration and types of stressors.