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Periodicity and prediction of mania onsets in biopolar I affective disorders
Author(s) -
MIZUKAWA ROKURO,
TSUSHIMA JOJI,
TAKADA TERUO,
NAGABUCHI TADABUMI,
WATANABE KEN,
HAZAMA HIDEBUMI
Publication year - 1996
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1111/j.1440-1819.1996.tb00559.x
Subject(s) - mania , psychology , bipolar disorder , cognitive psychology , clinical psychology , audiology , medicine , mood
In studying the periodicity of mania onsets, cycle‐oriented diagrams were made of the clinical course from 257 manic episodes analyzed retrospectively in 34 bipolar I manic‐depressive patients for a period of about 5 years. Using these diagrams, the frequent period of mania onsets located in one‐quarter of the follow‐up period was pre‐estimated, and the accordance ratio during a 25 month follow‐up period was analyzed. The accordance ratio in all subjects was 39% (11/28) for the first episode and 35% (7/20) for the second episode. These ratios were not significantly different from the expected level (25%). The number of subjects was limited to 11 patients (10 rapid and 1 non‐rapid cyclers) whose number of episodes used for the determination of the index cycle was eight or more. The accordance ratio was 64% (7/11) and 60% (6/10) for the first and second episodes, respectively. Their levels were significantly higher than those expected. Periodicity of mania onsets existed at least in rapid cyclers with abundant past data.